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The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055
CAS Number: 103404-90-6
It also down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo
21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H
Molecular Weight: 348
LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP The rapamycin-resistant T37/46 phosphorylation sitesLLY 507, CAS No. 1793053 37 8, is a potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor with IC50 <15 nM. It binds in the substrate peptide binding pocket. It has >100 fold selectivity over other methyltransferases and other non epigenetic targets. LLY 507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. It inhibited the proliferation of several esophageal, liver, and breast cancer cell
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