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PubMed PMID: 26701983
the only enzyme on which Sotrastaurin displays an IC50value below 1 μM is glycogen synthase kinase 3β
It also acts as a CDK4 inhibitor and inducer of the DNA damage response
PF-04979064 exhibited cellular potency with an IC50 of 9
body weight
Bay 11-7085 - CAS# 196309-76-9 Catalog No.:M6654-10 PubMed PMID: 26701983Bay 11 7085, CAS No. 196309 76 9, a soluble inhibitor of NK kappaB activation, has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. Bay 11 7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase 3 , 8 , and 9 mediated cascades are involved in this mechanism. Bay 11 7085 could be used as a therapeutic agent for the treatment of endometriosis. Bay 11 7085 protects against gut ischemia
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