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ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested
Smiles: OC(=O)CCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21
Bioorg Med Chem Lett
InChi: InChI=1S/C17H26N4O/c1-2-6-16-14(5-1)7-8-15(22-16)13-18-9-3-10-19-17-20-11-4-12-21-17/h1-2
Aza-peptidyl Michael acceptors
SR-318 Catalog No.:M28089-C ML241 (20 μM) shows noSR 318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6. 11 M for p38, p38 and p38 , respectively. SR 318 potently inhibits the TNF release in whole blood with an IC50 of 283 nM. SR 318 has anti cancer and anti inflammatory activity. Product information CAS Number: 2413286 32 3 Molecular Weight: 459. 58 Formula: C27H33N5O2 Chemical Name: 5 amino N ({4 [(3 cyclohexylpropyl)carbamoyl]phenyl}methyl) 1 phenyl 1H pyrazole
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