GSK J5 tan (medoxomil monopotassium) 40 µM in HepG2

40 µM in HepG2

14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy}-4-oxobut-2-enoic acid

Formula: C11H22N6O

CAS Number: 2320258-95-3

SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0

GSK J5 tan (medoxomil monopotassium) 40 µM in HepG2The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.,. GSK J4 is a cell permeable prodrug which is modified by intracellular esterases to give GSK J1, an inhibitor of JMJD3. GSK J5 is a pyridine regio isomer of GSK J4. Like GSK J4, this isomer is cell permeable and hydrolyzed to a free base. 3 However, the free base is a