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3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15
InChiKey: YEZCRNKNZWDABB-PZBWUIGESA-N
Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology
is a n orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities
and the effect is time and dose dependent
SAR405838 atel 3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15SAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0. 88 nM and has high specificity over other proteins. IC50 value: 0. 88 nM (Ki) [1] Target: MDM2 in vitro: SAR405838 potently inhibits cell growth in cancer cell lines, including SJSA 1 (IC50, 0. 092 M), RS4; 11 (IC50, 0. 089 M), LNCaP (IC50, 0. 27 M), and HCT 116 (IC50, 0. 20 M) cells, and displays high selectivity over cancer cell lines with mutated or deleted p53,
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