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InChi: InChI=1S/C22H18F2N4O3S/c1-12(2)32(30
CAS Number: 1001405-52-2
ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM
It was developed by Pfizer for the treatment of obesity
7 cells dose dependently at the early stage
GDC-0077 - CAS# 2060571-02-8 Catalog No.:M17007-C InChi: InChI=1S/C22H18F2N4O3S/c1-12(2)32(30GDC 0077 (RG6114) is a potent selective inhibitor of PI3K alpha (PI3K) with an IC50 of 0. 038 nM. GDC 0077 is >300 fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000 fold more selective over PIK family members. GDC 0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3. Product information CAS Number: 2060571 02 8 Molecular Weight: 407. 37 Formula: