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31(7):1604-11
InChi: InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H
Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis
Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1
16S)-6-hydroxy-16-{[(2R
COTI-2 nositol 31(7):1604-11COTI 2, an anti cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI 2 acts both by reactivating mutant p53 and inhibiting the PI3K AKT mTOR pathway. COTI 2 induces apoptosis in multiple human tumor cell lines. COTI 2 exhibits antitumor activity in HNSCC through p53 dependent and independent mechanisms. COTI 2 converts mutant p53 to wild type conformation. Product information CAS Number: 1039455 84