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InChiKey: OQAFDLPAPSSOHY-UHFFFAOYSA-N
X and DNA-PK-dependent pathway
Molecularly targeted therapies in non-small cell lung cancer: The evolving role of tyrosine kinase inhibitors
NSC59984 restores p53 pathway signaling through activation of p73
LDN193189 inhibits the induction of alkaline phosphatase activity in C2C12 cells by BMP4 even when administered 12 h after BMP stimulation
BIX 02189 - CAS# 1265916-41-3 122 InChiKey: OQAFDLPAPSSOHY-UHFFFAOYSA-NBIX 02189, CAS No. 1265916 41 3, is a selective MEK5 ERK5 inhibitor with an IC50 of 59 nM. BIX02189 was reported to inhibit catalytic function of purified, MEK5 enzyme. BIX02189 blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1 2 in sorbitol stimulated HeLa cells. BIX02189 also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5 ERK5 signaling cascade, in a cellular trans reporter assay system.
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