PS 1145 dihydrochloride 710ROTAC BRD2/BRD4 degrader-1 Ser422 and Ser262

Ser422 and Ser262

24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth

InChi: InChI=1S/C33H31BO12/c1-18(35)39-16-41-22-9-12-25-28(15-22)43-27-14-21(34-45-31(3

53-14)37(49)27(8)56-32)60-40-35(28(44(12)13)19-23(4)55-40)58-31(46)18-17-30(45)54-16-2/h22-29

PX-478 was used at 1-10 µM final concentration in various in vitro assays

PS 1145 dihydrochloride 710ROTAC BRD2/BRD4 degrader-1 Ser422 and Ser262Product information CAS Number: 1049743 58 9 Molecular Weight: 395. 67 Formula: C17H13Cl3N4O Chemical Name: (Z) N {6 chloro 9H pyrido[3,4 b]indol 8 yl}pyridine 3 carboximidic acid dihydrochloride Smiles: Cl. Cl. O C(=N\C1C=C(Cl)C=C2C=1NC1=CN=CC=C21) C1=CN=CC=C1 InChiKey: QTDCBADLGJZBHP UHFFFAOYSA N InChi: InChI=1S C17H11ClN4O. 2ClH c18 11 6 13 12 3 5 20 9 15(12)21 16(13)14(7 11)22 17(23)10 2 1 4 19 8 10;; h1 9,21H,(H,22,23); 2*1H Technical Data