N-Methylmoranoline decreases the alpha-1
Formula: C2H4N6
29(2):371-80
Smiles: [2H]C1([2H])C([2H])([2H])C(OC2=CC(=CC=C2OC)C2(CCC(CC2)C(O)=O)C#N)C([2H])([2H])C1([2H])[2H]
CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36
CHMFL-PI3KD-317 Size:Contact [email protected] for quotation N-Methylmoranoline decreases the alpha-1CHMFL PI3KD 317 is a highly potent, selective and orally active PI3K inhibitor, with an IC50 of 6 nM, and exhibits over 10 1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3K (IC50, 62. 6 nM), PI3K (IC50, 284 nM), PI3K (IC50, 202. 7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882. 3 nM), VPS34 (IC50, 1801. 7 nM), PI4KIIIA (IC50, 574. 1 nM) and PI4KIIIB (IC50, 300. 2 nM). CHMFL PI3KD 317 inhibits PI3K mediated Akt