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PubMed PMID: 16889941
Emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well
Body weight measurement and analysis reveal that the mice treated with WZB117 lost about 1 to 2 grams of body weight compared with the mock-treated mice with most of the weight loss in the fat tissue
10 nM and 36 nM
InChi: InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H
SN-38 Size:Solid 2 mg PubMed PMID: 16889941SN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be
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