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Chemical Name: 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2
displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo
tight-binding kinetics) of LpxC from Rhizobium leguminosarum (Ki=340 nM)
LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2
This leads to an inhibition of the growth of malignant B cells that overexpress BTK
Dabrafenib - CAS# 1195765-45-7 size:2mg solid Chemical Name: 2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2Dabrafenib, CAS No. 1195765 45 7, also known as GSK2118436 , is an orally bioavailable inhibitor of B raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B raf belongs to the the raf mil family of serine threonine protein kinases and plays a role in regulating the MAP kinase ERKs signaling
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