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Quizartinib (AC220) inhibits FLT3 activity in vivo
2013 Nov 28
which is relatively rare in the total population
brain penetrance
(-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor
LC-2, PROTACs for KRAS orvastatin (hemicalcium salt) Quizartinib (AC220) inhibits FLT3 activityLC 2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines. Product information CAS Number: 2502156 03 6 Molecular Weight: 1132. 78 Formula: C59H71ClFN11O7S Chemical Name: (2S,4R) 1 [(2S) 2 (3 {3 [(2S) 2 ({[7 (8
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