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J Oncol Pract
CAS Number: 300842-64-2
Cumulatively these combined profiling technologies demonstrate that both JNK-IN-8 and JNK-IN-12 are remarkably selective covalent JNK inhibitors and are appropriate for interrogating JNK-dependent biological phenomena
InChi: InChI=1S/C26H32N4O8/c31-21(9-13-29-24(34)7-8-25(29)35)27-12-16-38-18-17-37-15-11-22(32)28-20-4-1-19(2-5-20)3-6-23(33)30-14-10-26(30)36/h1-2
Body weight measurement and analysis reveal that the mice treated with WZB117 lost about 1 to 2 grams of body weight compared with the mock-treated mice with most of the weight loss in the fat tissue
GSK-25 - CAS# 874119-56-9 60275 J Oncol PractGSK 25, CAS No. 874119 56 9, is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK 25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 M). GSK 25 inhibits P450 profile (IC50s of 2. 5, 5. 2, 2. 5 M for CYP2C9, CYP2D6, CYP3A4, respectively). Product information CAS Number: 874119 56 9 Molecular Weight: 513. 33 Formula: C24H16Cl2F2N6O Chemical
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