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4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
is a potent and selective Pim protein kinase inhibitor
CAS Number: 1604810-83-4
USP10 and USP13
6-fold resistant to crenolanib
KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60166 4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-oneKYA1797K, CAS No. 1956356 56 1, is a highly potent and selective Wnt catenin inhibitor with IC50 ~0. 75 M (TOPflash assay). It binds directly to the regulators of G protein signaling domain of axin, initiating catenin and Ras degradation through enhancement of the catenin destruction complex activating GSK3. KYA1797K can effectively suppress the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo
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