IRAK4-IN-6 - CAS# 2454244-02-9 nanthrene InChi: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9

InChi: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9

levels of Ryr3 are increased to 76% of WT level

Vecabrutinib shows an IC50 of 24 nM for ITK

This drug acts by inhibiting the synthesis of bacterial cell walls

but appeared to enhance LPS-induced secretion of IL-8 in PHM1-41 cells

IRAK4-IN-6 - CAS# 2454244-02-9 nanthrene InChi: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9IRAK4 IN 6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma. Product information CAS Number: 2454244 02 9 Molecular Weight: 504. 59 Formula: C25H32N10O2 Chemical Name: methyl 4 [(1r,4r) 4 {[6 (cyanomethyl) 2 [(1 methyl 1H pyrazol 4 yl)amino]pyrido[3,2 d]pyrimidin 4 yl]amino}cyclohexyl]piperazine 1 carboxylate Smiles: